A 31-year-old woman with a history of Cushing disease presented to the endocrinology
clinic with progressively worsening hyperpigmentation of the oral cavity and palmar
creases (Figure A & B). Medical history was significant for transsphenoidal resection of an ACTH-secreting
pituitary adenoma followed by radiation therapy. Subsequently, bilateral adrenalectomy
was performed due to ongoing cortisol excess that was refractory to medical treatment.
The patient was prescribed adrenal replacement therapy with hydrocortisone and fludrocortisone.
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References
- Nelson syndrome: comprehensive review of pathophysiology, diagnosis, and management.Neurosurg Focus. 2007; 23 (PMID: 179610): E13https://doi.org/10.3171/foc.2007.23.3.15
- The long-term outcome after adrenalectomy and prophylactic pituitary radiotherapy in adrenocorticotropin-dependent Cushing's syndrome.J Clin Endocrinol Metab. 1995 Jan; 80 (PMID: 7829606): 165-171https://doi.org/10.1210/jcem.80.1.7829606
- Temozolomide treatment in aggressive pituitary tumors and pituitary carcinomas: a French multicenter experience.J Clin Endocrinol Metab. 2010 Oct; 95 (Epub 2010 Jul 21PMID: 20660056): 4592-4599https://doi.org/10.1210/jc.2010-0644
Article info
Publication history
Published online: March 17, 2023
Accepted:
March 14,
2023
Received:
February 9,
2023
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
