Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by a dysregulated
inflammatory response that targets primarily the synovium though other extra-articular
tissues can be affected too.
1
A higher morbidity and mortality have been associated with a subset of patients who
eventually developed extra articular manifestations, such as interstitial lung disease
and rheumatoid vasculitis. Pathogenesis of RA is complex, but a combination of genetic
and environmental factors has been identified, including the presence of the “shared
epitope” HLA-DRB1 and tobacco use.To read this article in full you will need to make a payment
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Article info
Publication history
Published online: February 22, 2023
Accepted:
February 14,
2023
Received:
February 7,
2023
Identification
Copyright
© 2023 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
