A 59-year-old male who had been diagnosed with small cell hypochromic anemia caused
by iron deficiency, presented to thoracic clinic with chest pain. Thirty years ago,
he had underwent colectomy for intestinal obstruction and worked in plateau area.
Physical examination was normal. Laboratory data included mean white blood cell count
of 10.10x109 per litre (reference range, 3.5 to 9.5), mean reticulocyte count of 0.1022x1012 per litre (reference range, 0.024 to 0.084), mean platelet count of 75 x109 per litre (reference range, 125 to 350), mean corpuscular volume of 74.40 femtoliters
(reference range, 82 to 100), mean corpuscular hemoglobin of 23.30 peta-grams (reference
range, 27 to 34), mean corpuscular hemoglobin concentration of 313 grams per limiter
(reference range, 316 to 354). Abdominal ultrasound showed splenomegaly. Non-contrast
chest CT found bilateral, broad base, posterior mediastinal mass (Fig. 1A). Magnetic resonance imaging revealed two equal, enhancement parenchymal, paravertebral
masses, without adjacent bone or intervertebral foramen invasion (Fig. 1B). Pathological examination confirmed as extramedullary hematopoiesis by thoracoscopic
biopsy (Fig. 1C). The patient was followed up in the hematology clinic postoperatively.
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References
- The mechanisms of pathological extramedullary hematopoiesis in diseases.Cell Mol Life Sci. 2020; 77 (Epub 2020 Jan 23. PMID: 31974657): 2723-2738https://doi.org/10.1007/s00018-020-03450-w
- Chapter Three - Extramedullary hematopoiesis in myeloproliferative neoplasms: Pathophysiology and treatment strategies.Rev Cell Mol Biol, Acad Press. 2021; 365 (Pages 97-116,ISSN 1937-6448,ISBN 9780323899390)
- Optimal treatment of intrathoracic extramedullary hematopoiesis resembling posterior mediastinal tumor; report of a case.Kyobu Geka. 2005; 58 (Japanese. PMID: 16104573): 835-837
Article info
Publication history
Published online: February 21, 2023
Accepted:
February 8,
2023
Received:
October 31,
2022
Publication stage
In Press Journal Pre-ProofFootnotes
No conflict of interest exits and no funding source was received.
Identification
Copyright
© 2023 Published by Elsevier Inc. on behalf of Southern Society for Clinical Investigation.
