Abstract
Background
The hypertriglyceridemia waist (HTGW) phenotype is associated with visceral adiposity,
metabolic syndrome, type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular
disease (ASCVD). Since the cut points for abdominal obesity and hypertriglyceridemia,
differ for different race groups, investigators have developed the product of triglycerides
(TG) and waist circumference (WC) as the TG.WC index. We compared this TG.WC index
to the TG:HDL-C ratio in the National Health and Nutrition Examination Survey (NHANES)
study to predict metabolic syndrome (MetS) in African Americans (AAs).
Methods
Participants included 950 AAs and 2651 non-Hispanic Whites (NHWs) for comparison from
the NHANES data set. Persons with diabetes, ASCVD and macro-inflammation were excluded.
Fasting blood was obtained for lipids, insulin and CRP.
Results
In AAs and NHWs, both the TG.WC index and TG:HDL-C ratio were significantly increased
in MetS patients. Also, both increased with increasing severity of MetS and correlated
with all features of MetS, insulin resistance and inflammation. Receiver operating
characteristic (ROC) curve analysis showed that discrimination with TG.WC for MetS
was superior to the TG:HDL-C ratio especially in AAs.
Conclusions
TG.WC index is a superior biomarker to TG:HDL-C for predicting MetS in AAs despite
their lower TG levels.
Keywords
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Article info
Publication history
Published online: November 22, 2022
Accepted:
November 17,
2022
Received:
September 21,
2022
Identification
Copyright
Published by Elsevier Inc. on behalf of Southern Society for Clinical Investigation.
