Abstract
Background
The visceral adiposity index (VAI) is a new marker of adipose dysfunction and related
with cardiometabolic risk. The aim of this study is to investigate the association
of VAI with arterial stiffness in elderly Chinese population.
Methods
A total of 1,707 elderly individuals over 60 years of age were recruited for this
cross-sectional study. We measured body composition, anthropometrics, blood pressure,
and lipid parameters. The arterial stiffness was measured by brachial-ankle pulse
wave velocity (baPWV) and defined as baPWV ≥ 1400 cm/s. VAI was calculated based
on body mass index, waist circumference, triglyceride and high-density lipoprotein
cholesterol. Multivariable regression analysis was performed to evaluate the association
between VAI and baPWV.
Results
There were significant differences in VAI tertiles between low-baPWV and high-baPWV
group (p = 0.008). Univariate analysis demonstrated that age, history of hypertension, SBP,
DBP, total cholesterol, fasting glucose, the higher VAI tertiles were correlated with
the existence of high-baPWV (p < 0.05). Participants in the higher VAI tertiles had higher OR (1.0 ≤ VAI < 1.74:
OR= 2.89, 95% CI [1.44, 5.80]; VAI ≥ 1.75: OR = 4.23, 95% CI [1.45, 12.37], p for trend: 0.004) comparing with the lowest VAI tertile. Non-linear relationship
was detected between VAI and baPWV. VAI was positively correlated with baPWV when
VAI < 2.10.
Conclusions
This study demonstrates that VAI is independently associated with the risk of arterial
stiffness in elderly population.
Keywords
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References
- Body fat distribution and risk of cardiovascular disease: an update.Circulation. 2012; 126: 1301-1313https://doi.org/10.1161/CIRCULATIONAHA.111.067264
- Obesity and Cardiovascular Disease.Circ Res. 2016; 118: 1752-1770https://doi.org/10.1161/CIRCRESAHA.115.306883
- A Body Shape Index and Body Roundness Index: Two New Body Indices to Identify left Ventricular Hypertrophy among Rural Populations in Northeast China.Heart Lung Circ. 2016; 25: 358-364https://doi.org/10.1016/j.hlc.2015.08.009
- Increased visceral fat accumulation modifies the effect of insulin resistance on arterial stiffness and hypertension risk.Nutr Metab Cardiovasc Dis. 2021; 31: 506-517https://doi.org/10.1016/j.numecd.2020.09.031
- Differential association of visceral adipose tissue with coronary plaque characteristics in patients with and without diabetes mellitus.Cardiovasc Diabetol. 2014; 13: 61https://doi.org/10.1186/1475-2840-13-61
- Visceral adipose tissue area is associated with coronary stenosis and noncalcified plaques.Int J Obes (Lond). 2014; 38: 272-278https://doi.org/10.1038/ijo.2013.105
- Surrogate markers of visceral adiposity in young adults: waist circumference and body mass index are more accurate than waist hip ratio, model of adipose distribution and visceral adiposity index.PLoS One. 2014; 9e114112https://doi.org/10.1371/journal.pone.0114112
- Anthropometric indices as surrogates for estimating abdominal visceral and subcutaneous adipose tissue: A meta-analysis with 16,129 participants.Diabetes Res Clin Pract. 2018; 143: 310-319https://doi.org/10.1016/j.diabres.2018.08.005
- Visceral Adiposity Index: a reliable indicator of visceral fat function associated with cardiometabolic risk.Diabetes Care. 2010; 33: 920-922https://doi.org/10.2337/dc09-1825
- The visceral adiposity index as a predictor of insulin resistance in young women with polycystic ovary syndrome.Obesity (Silver Spring). 2013; 21: 1690-1694https://doi.org/10.1002/oby.20096
- Utility of the Visceral Adiposity Index and Hypertriglyceridemic Waist Phenotype for Predicting Incident Hypertension.Endocrinol Metab (Seoul). 2017; 32: 221-229https://doi.org/10.3803/EnM.2017.32.2.221
- Arterial stiffness and cardiovascular events: the Framingham Heart Study.Circulation. 2010; 121: 505-511https://doi.org/10.1161/CIRCULATIONAHA.109.886655
- Arterial stiffness as a risk factor for clinical hypertension.Nat Rev Cardiol. 2018; 15: 97-105https://doi.org/10.1038/nrcardio.2017.155
- Brachial-ankle pulse wave velocity predicts all-cause mortality and cardiovascular events in patients with diabetes: the Kyushu Prevention Study of Atherosclerosis.Diabetes Care. 2014; 37: 2383-2390https://doi.org/10.2337/dc13-1886
- Arterial Stiffness.Pulse (Basel). 2013; 1: 14-28https://doi.org/10.1159/000348620
- Obesity and related consequences to ageing.Age (Dordr). 2016; 38: 23https://doi.org/10.1007/s11357-016-9884-3
- Sex differences in fat distribution influence the association between BMI and arterial stiffness.J Hypertens. 2017; 35: 1219-1225https://doi.org/10.1097/HJH.0000000000001297
- Visceral adiposity index may be a surrogate marker for the assessment of the effects of obesity on arterial stiffness.PLoS One. 2014; 9e104365https://doi.org/10.1371/journal.pone.0104365
- Arterial Stiffness Preceding Diabetes: A Longitudinal Study.Circ Res. 2020; 127: 1491-1498https://doi.org/10.1161/CIRCRESAHA.120.317950
- Aging, Arterial Stiffness, and Blood Pressure Association in Chinese Adults.Hypertension. 2019; 73: 893-899https://doi.org/10.1161/HYPERTENSIONAHA.118.12396
- A cross-sectional study of the relationships between different components of sarcopenia and brachial ankle pulse wave velocity in community-dwelling elderly.BMC Geriatr. 2020; 20: 115https://doi.org/10.1186/s12877-020-01525-8
- Hypertension, Arterial Stiffness, and Diabetes: a Prospective Cohort Study.Hypertension. 2022; 79: 1487-1496https://doi.org/10.1161/HYPERTENSIONAHA.122.19256
- Association between organ damage and visceral adiposity index in community-dwelling elderly Chinese population: the Northern Shanghai Study.Aging Clin Exp Res. 2021; 33: 2291-2297https://doi.org/10.1007/s40520-020-01752-4
- Aortic Stiffness Is Associated With Visceral Adiposity in Older Adults Enrolled in the Study of Health, Aging, and Body Composition.Hypertension. 2001; 38: 429-433https://doi.org/10.1161/01.HYP.38.3.429
- Relationship of Adiposity to Subclinical Atherosclerosis in Obese Patients with Type 2 Diabetes.Obesity Research. 2003; 11: 1597-1605https://doi.org/10.1038/oby.2003.212
- Brachial-Ankle Pulse Wave Velocity and the Risk Prediction of Cardiovascular Disease: An Individual Participant Data Meta-Analysis.Hypertension. 2017; 69: 1045-1052https://doi.org/10.1161/HYPERTENSIONAHA.117.09097
- Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection.Hypertension. 2008; 51: 1651-1657https://doi.org/10.1161/HYPERTENSIONAHA.107.105668
- Aortic pulse wave velocity and the degree of atherosclerosis in the elderly: a pathological study based on 304 autopsy cases.Atherosclerosis. 2005; 179: 345-351https://doi.org/10.1016/j.atherosclerosis.2004.09.023
- Predictors of insulin resistance in patients with obesity: a pilot study.Angiology. 2014; 65: 22-30https://doi.org/10.1177/0003319712468291
- Adipokines, inflammation, and visceral adiposity across the menopausal transition: a prospective study.J Clin Endocrinol Metab. 2009; 94: 1104-1110https://doi.org/10.1210/jc.2008-0701
Article info
Publication history
Published online: November 03, 2022
Accepted:
October 13,
2022
Received:
September 28,
2021
Footnotes
Clinical Trial Registration—URL: http://www.chictr.org/cn/proj/show.aspx?proj=1441.
Unique identifier: ChiCTR-TNC-11001489.
Identification
Copyright
© 2022 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
