Blood chemistry panel and body mass index (BMI) are common ways to evaluate individual health. The study aimed to compare a wide range of blood chemistry tests between obese, overweight, and normal weight populations that are otherwise apparently healthy.
We conducted a cross-sectional study of all adults (20-65 years) with BMI ≥18.5 kg/m2 who underwent routine annual health check-ups. Participants who had any known morbidity or taking medication were excluded. BMI was categorized using the current World Health Organization criteria. After fasting, glucose, renal and liver functions, albumin and total protein levels, lipid profile, electrolytes levels and inflammatory marker were observed and compared between BMI categories.
The study included 10,211 adults (median BMI 25.1 kg/m2, 48.8% normal weight, 39.7% overweight, 11.5% obese). The mean age was 40.78 years (SD 9.69) and 35.4% were female. Triglyceride level was 23.5% in overweight and 50.6% higher in obese participants (p < 0.001). Liver enzymes were higher in overweight (5.6-18.7%, p < 0.001) and obese participants (13.4-48.3%, p < 0.001). C-reactive protein level was 134% higher in overweight and 430% higher in obese participants (p < 0.001). Differences were also documented in other blood tests.
Overweight and obesity were found to be associated with significant abnormalities in blood tests. A periodic wide panel of blood tests, especially for overweight and obese populations, is essential to identify and intervene as secondary prevention before the onset of symptoms.
Key Indexing Terms
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- Baseline tests or screening: what tests do family physicians order routinely on their healthy patients?.J Med Screen. 2002; 9: 133-134
- Review of systems, physical examination, and routine tests for case-finding in ambulatory patients.Am J Med Sci. 1995; 309: 194-200
- Evidence brief: role of the annual comprehensive physical examination in the asymptomatic adult.VA Evidence Synthesis Program Evidence Briefs [Internet]. Washington (DC): Department of Veterans Affairs (US), 2011
- Preventive care checklist form. Evidence-based tool to improve preventive health care during complete health assessment of adults.Can Fam Physician. 2006; 52: 48-55
- Routine preoperative testing: a systematic review of the evidence.Health Technol Assess. 1997; 1: 1-62
- Screening tests among family doctors: do we do as we preach?.Public Health. 2013; 127: 282-289
- Use of blood tests in general practice: a collaborative study in eight European countries. Eurosentinel Study Group.Br J Gen Pract. 1995; 45: 21-25
- Support of evidence-based guidelines for the annual physical examination: a survey of primary care providers.Arch Intern Med. 2005; 165: 1347-1352
- The association between C-reactive protein and common blood tests in apparently healthy individuals undergoing a routine health examination.Clin Chim Acta. 2020; 501: 33-44
- Preventive Services Task Force Evidence Syntheses, formerly Systematic Evidence Reviews.Agency for Healthcare Research and Quality (US), Rockville (MD)1998
- Screening for and Management of Obesity and Overweight in Adults.Agency for Healthcare Research and Quality (US), Rockville (MD)2011
- Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults - The Evidence Report. National Institutes of Health.Obes Res. 1998; 6: 51S-209S
- Report of a WHO consultation, World Health Organ.Tech Rep Ser. 2000; 894: 1-253
- Overweight and obesity: prevalence, consequences, and causes of a growing public health problem.Curr Obes Rep. 2015; 4: 363-370
- Obesity—United States, 1999–2010 in: morbidity and mortality weekly report: division of nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion.CDC. 2013; : 120-128
- Obesity as a medical problem.Nature. 2000; 404: 635-643
- Overweight and obesity: prevalence, consequences, and causes of a growing public health problem.Am J Med Sci. 2006; 331: 166-174
- Obesity Epidemiology Worldwide.Gastroenterol Clin North Am. 2016; 45: 571-579
- Morbidity and mortality associated with obesity.Ann Transl Med. 2017; 5: 161
- Obesity. Lancet. 2005; 366: 1197-1209https://doi.org/10.1016/S0140-6736(05)67483-1
- The impact of obesity on diabetes mellitus and the role of bariatric surgery.Maturitas. 2011; 69: 137-140
- Adipokines: a link between obesity and cardiovascular disease.J Cardiol. 2014; 63: 250-259
- Low glomerular density with glomerulomegaly in obesity-related glomerulopathy.Clin J Am Soc Nephrol. 2012; 7: 735-741
- Non-alcoholic fatty liver disease: a massive problem.Clin Med (Lond.). 2011; 11: 176-178
- Hepatic histology in obese patients undergoing bariatric surgery.J Hepatol. 2006; 45: 600-606
- Association between body mass index and fatty liver risk: a dose-response analysis.Sci Rep. 2018; 8: 15273
- Nonalcoholic fatty liver disease.Am Fam Physician. 2006; 73: 1961-1968
- New trends on obesity and NAFLD in Asia.J Hepatol. 2017; 67: 862-873
- Obesity, adiposity, and dyslipidemia: a consensus statement from the National Lipid Association.J Clin Lipidol. 2013; 7: 304-383
- Obesity, metabolic syndrome, and cardiovascular disease.J Clin Endocrinol Metab. 2004; 89: 2595-2600
- Obesity and dyslipidemia.Med Clin North Am. 2011; 95: 893-902
- Dyslipidemia in obesity: mechanisms and potential targets.Nutrients. 2013; 5: 1218-1240
- Obesity is the major determinant of elevated C-reactive protein in subjects with the metabolic syndrome.Int J Obes Relat Metab Disord. 2004; 28: 674-679
- The characteristics of impaired fasting glucose associated with obesity and dyslipidaemia in a Chinese population.BMC Public Health. 2010; 10: 139
- The ability of the wide range CRP assay to classify individuals with low grade inflammation into cardiovascular risk groups.Clin Chim Acta. 2017; 471: 185-190
- Weakened cholinergic blockade of inflammation associates with diabetes-related depression.Mol Med. 2016; 22: 156-161
- Characteristics of apparently healthy individuals with a very low C-reactive protein.Clin Chim Acta. 2019; 495: 221-226
- Diagnosis and management of the metabolic syndrome. An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Executive summary.Circulation. 2005; 112: e285-e290
- Adipose tissue as an endocrine organ.J Clin Endocrinol Metab. 2004; 89: 2548-2556
- Increase of body mass index and waist circumference predicts development of metabolic syndrome criteria in apparently healthy individuals with 2 and 5 years follow-up.Int J Obes. 2019; 43: 800-880
- Clinical application of C-reactive protein for cardiovascular disease detection and prevention.Circulation. 2003; 28: 363-369
- C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women.Circulation. 2003; 107: 391-397
- C-reactive protein, the metabolic syndrome, and prediction of cardiovascular events in the Framingham Offspring Study.Circulation. 2004; 110: 380-385
Published online: September 19, 2022
Accepted: July 27, 2022
Received: November 14, 2021
Postal address: Tel Aviv University - P.O.B. 39040, Tel Aviv 6997801, Israel.
Tel Aviv Sourasky Medical Center - 6 Weizmann Street, Tel Aviv 6423906, Israel.
© 2022 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.