Abstract
Background
This study aims to analyze the association of obstructive sleep apnea (OSA) with endothelial
function and heart structure in patients with hypertension and lay a clinical foundation
for preventing and treating endothelial dysfunction and heart remodeling in patients
with hypertension.
Methods
A cross-sectional study design was adopted in this study. From April 2020 to April
2021, 143 patients with hypertension were included and classified into two groups
according to the severity of OSA: 81 patients with hypertension without OSA [apnea-hypopnea
index (AHI) < 5 events/hour] serving as the control group; 62 patients with hypertension
with moderate-severe OSA (AHI ≥ 15 events/hour) serving as the OSA group. The endothelial
function and heart structure were assessed by flow‐mediated vasodilation (FMD) and
transthoracic echocardiography. Logistic regression analyses were conducted to identify
factors associated with endothelial dysfunction and heart remodeling.
Results
Compared with the control group, patients with OSA had significantly greater interventricular
septal thickness (IVST) and left ventricular posterior wall thickness (LVPWT) (P < 0.05), and FMD exhibited a significant decrease (P < 0.05). Logistic regression analyses demonstrated that gender and AHI were associated
with FMD (P < 0.05), and FMD was associated with LVMI (P < 0.05).
Conclusions
OSA was associated with endothelial dysfunction and heart remodeling in patients with
hypertension. Endothelial dysfunction may be crucial for the development of heart
remodeling in patients with hypertension with OSA.
Keywords
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Article info
Publication history
Published online: August 22, 2022
Accepted:
August 17,
2022
Received:
September 13,
2021
Identification
Copyright
© 2022 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
