Abstract
Background
Eosinophil count, dyslipidemia, and metabolic syndrome (MetS) are associated with
systemic inflammation. We conducted this large population-based study to investigate
the association between elevated eosinophil count, serum lipids, and MetS in the Taiwanese
population.
Methods
A cross-sectional study of 10,357 adults who underwent health checkups at Shin Kong
Wu Ho-Su Memorial Hospital in Taiwan between January 2006 and December 2016 was conducted.
MetS was defined according to criteria modified by the International Diabetes Federation
specifically for the Chinese population. The measurement of serum lipids included
high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol
(LDL-C), apolipoprotein A-I (ApoA-I), and apolipoprotein B (ApoB). Pearson's correlation
and linear regression were used to determine the association of eosinophil count with
waist circumference, blood pressure, fasting glucose, and serum lipids. Multivariate
logistic regression analysis was used to determine the odds ratio of MetS and abnormal
serum lipid levels in each eosinophil count quartile.
Results
Eosinophil count was positively associated with triglycerides levels and negatively
associated with HDL-C levels; however, it was not significantly associated with ApoA-I
and ApoB. The odds ratio of MetS increased significantly across eosinophil count quartiles.
The adjusted odds ratios of MetS for the second, third, and fourth quartiles were
1.28, 1.38, and 1.42, respectively, with reference to the first quartile.
Conclusions
High eosinophil count is an independent risk factor for MetS. Hypertriglyceridemia
and hypo-HDL-cholesterolemia might partly contribute to this result.
Key Indexing Terms
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Article info
Publication history
Published online: July 30, 2022
Accepted:
July 27,
2022
Received:
May 3,
2021
Identification
Copyright
© 2022 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
