Abstract
Background
The aim of this study was to analyze the relationship between sodium taurocholate
cotransporting polypeptide (NTCP) gene varieties and hepatitis B virus (HBV) infection
and the progress of HBV-related liver disease.
Methods
PubMed, EMBASE, Web of Science and Cochrane library were used to search eligible studies.
STATA software was performed to combine results. Pooled odds ratios (OR) was used
to assess the potential genetic relationships.
Results
A total of 18 eligible case-control studies with 24960 cases and 28342 controls were
included in this meta-analysis. The A allele of rs2296651 polymorphism was found to
be significantly linked to a protection of HBV infection in the whole combined analysis
(P = 0.000). Meanwhile, this allele was significantly associated with a decreased
risk of hepatocellular carcinoma (HCC) (A vs. G: OR = 0.668, 95% CI: 0.571-0.782,
P = 0.000), and was significantly associated with HBV nature clearance (A vs. G: OR = 0.744,
95% CI: 0.585-0.946, P = 0.016; AA+GA vs. GG: OR = 0.775, 95% CI: 0.613-0.980, P = 0.033;
GA vs. GG: OR = 0.748, 95% CI: 0.588-0.952, P = 0.018). However, rs4646287 genetic
varieties had no statistical differences in all models with HBV infection or HBV-related
disease progress, liver cirrhosis, acute-on-chronic liver failure and HCC, as well
as rs7154439, rs4646285, rs4646296.
Conclusions
Rs2296651 polymorphism (A allele) may protect from HBV infection and the progress
of HBV-related disease (HBV-related HCC). Future research about other single nucleotide
polymorphisms (SNPs) (rs4646287, rs7154439, rs4646285, rs4646296) of NTCP may be needed
to clarify the relationship of NTCP gene varieties with HBV infection and HBV-related
disease.
Key Indexing Terms
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Article info
Publication history
Published online: April 06, 2022
Accepted:
March 7,
2022
Received:
August 16,
2020
Identification
Copyright
© 2022 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
