Abstract
Aspergillus species are ubiquitous in the environment. Aspergillosis is acquired by inhalation
of Aspergillus spores. In normal hosts, spore inhalation rarely causes lung disease. Pulmonary Aspergillosis
covers a wide spectrum of clinical syndromes depending on the interaction between
Aspergillus and the host (immune-status, prior bronchopulmonary disease). It runs the gamut from
invasive Aspergillosis to Aspergillus bronchitis. Invasive Aspergillosis usually occurs
in severely immunocompromised patients, typically in neutropenic but also in non-neutropenic
patients. Chronic pulmonary Aspergillosis affects patients with chronic structural
lung disease such as COPD or previous mycobacterial lung disease, but without other
significant immunocompromise. Aspergillus bronchitis affects patients with bronchial disease such as bronchiectasis. Allergic
bronchopulmonary Aspergillosis affects patients with bronchial asthma or cystic fibrosis,
and is due to an allergic response to Aspergillus.
Key Indexing Terms
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References
- Pulmonary and sinus fungal diseases in non-immunocompromised patients.Lancet Infect Dis. 2017; 17: e357-ee66
- The clinical spectrum of pulmonary aspergillosis.Thorax. 2015; 70: 270-277
- Diagnosis and treatment of pulmonary aspergillosis syndromes.Chest. 2014; 146: 1358-1368
- Pulmonary aspergillosis: a clinical review.Eur Respir Rev. 2011; 20: 156-174
- Aspergillosis.N Engl J Med. 2009; 360: 1870-1884
- Invasive aspergillosis in the intensive care unit.Clin Infect Dis. 2007; 45: 205-216
- Revised definitions of invasive fungal disease from the European organization for research and treatment of cancer/invasive fungal infections cooperative group and the national institute of allergy and infectious diseases mycoses study group (EORTC/MSG) consensus group.Clin Infect Dis. 2008; 46: 1813-1821
- Microbiological laboratory testing in the diagnosis of fungal infections in pulmonary and critical care practice. An official american thoracic society clinical practice guideline.Am J Respir Crit Care Med. 2019; 200: 535-550
- Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis.N Engl J Med. 2002; 347: 408-415
- Practice guidelines for the diagnosis and management of aspergillosis: 2016 update by the infectious diseases society of America.Clin Infect Dis. 2016; 63: e1-e60
- Commentary: unusual manifestations of aspergillosis.Thorax. 1995; 50: 812-813
- Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the infectious diseases society of America.Clin Infect Dis. 2011; 52: 427-431
- Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management.Eur Respir J. 2016; 47: 45-68
- A modern series of percutaneous intracavitary instillation of amphotericin B for the treatment of severe hemoptysis from pulmonary aspergilloma.Chest. 2013; 143: 1414-1421
- Invasive pulmonary aspergillosis in patients with influenza infection: report of two cases and systematic review of the literature.Expert Rev Respir Med. 2015; 9: 89-96
- Invasive aspergillosis associated with severe influenza infections.Open Forum Infect Dis. 2016; 3 (ofw171)
- Aspergillus bronchitis without significant immunocompromise.Ann N Y Acad Sci. 2012; 1272: 73-85
- Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria.Clin Exp Allergy. 2013; 43: 850-873
- Developments in the diagnosis and treatment of allergic bronchopulmonary aspergillosis.Expert Rev Respir Med. 2016; 10: 1317-1334
- Recurrent pulmonary embolism and hypersensitivity pneumonitis secondary to aspergillus, in a compost plant worker: case report and review of literature.Lung. 2018; 196: 553-560
- Hypersensitivity pneumonitis versus invasive pulmonary aspergillosis: two cases with unusual pathologic findings and review of the literature.Am Rev Respir Dis. 1991; 143: 431-436
- Hypersensitivity pneumonitis caused by fungi.Proc Am Thorac Soc. 2010; 7: 229-236
- Diagnosis of hypersensitivity pneumonitis in adults. An official ATS/JRS/ALAT clinical practice guideline.Am J Respir Crit Care Med. 2020; 202: e36-e69
- Hypersensitivity pneumonitis: perspectives in diagnosis and management.Am J Respir Crit Care Med. 2017; 196: 680-689
Article info
Publication history
Published online: December 12, 2020
Accepted:
December 10,
2020
Received:
July 27,
2020
Identification
Copyright
© 2021 Published by Elsevier Inc. on behalf of Southern Society for Clinical Investigation.
