Abstract
Background
The association between uric acid and N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP)
in patients with unstable angina pectoris (UAP) is unclear.
Methods
We recruited 260 patients with UAP admitted to the first affiliated Hospital of Guangxi
Medical University from February 2018 to August 2018. According to the level of uric
acid, patients were divided into 4 groups (Q1 = 48.00-305.00 μmol/L; Q2 = 310.00-405.00
μmol/L; Q3 = 408.00-513.00 μmol/L; Q4 = 514.00-4330.00 μmol/L). The differences of
NT-proBNP between groups and the relationship with cardiac function were compared.
Results
The average age of the 260 patients enrolled was 75.04 years. The NT-proBNP of the
4 groups showed an increasing trend, and there were significant differences between
the 4 groups (<0.001). On the other hand, with the increase of cardiac function (New
York Heart Association), the levels of NT-proBNP and uric acid also showed an upward
trend (all P < 0.05). Pearson correlation analysis showed that there was a positive correlation
between uric acid log10 transform and NT-proBNP log10 transform (r = 0.272, P < 0.001). After adjusting the potential confounding factors, elevated uric acid was
still significantly related to the increase of NT-proBNP (Q2 versus [vs.] Q1: OR = 469.64,
95%CI −1396.77 to 2336.05; Q3 vs. Q1: OR = 1166.53, 95%CI −726.12 to 3059.18; Q4 vs.
Q1: OR = 3204.78, 95%CI 1240.86-5168.70). In subgroup analysis, the relationship between
uric acid and NT-proBNP was significant in males, but no difference was observed in
females.
Conclusions
In male patients with UAP, elevated uric acid is related to the increase of NT-proBNP,
but this phenomenon is not obvious in female patients.
Key Indexing Terms
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Article info
Publication history
Published online: April 10, 2020
Accepted:
April 2,
2020
Received:
December 24,
2019
Footnotes
Funding: None.
Conflict of Interest: There are no conflicts of interest.
Identification
Copyright
© 2020 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
