Abstract
Background
Numerous studies have demonstrated that patients with non-O blood groups have a higher
risk for venous thromboembolism than those with the O blood group. However, the effect
of ABO blood groups on warfarin dose requirements in patients receiving anticoagulation
in the Chinese Han population remains unknown. This study aimed to investigate the
influence of ABO blood groups on warfarin dose requirements in a Chinese Han population.
Material and Methods
A retrospective study was conducted in the First Affiliated Hospital of Shantou University
Medical College in South China. Three hundred and fifty-eight patients with a confirmed
diagnosis of deep vein thrombosis or atrial fibrillation were included. The frequency
of blood groups and warfarin dose requirements were determined.
Results
Of 358 patients with deep vein thrombosis or atrial fibrillation, 111 patients had
blood group A (31.01%), 104 patients had blood group B (29.05%), 20 patients had blood
group AB (5.59%) and 123 patients had blood group O (34.36%). The patients in the
O blood group had lower warfarin dose requirements than those in the A, B and AB blood
groups.
Conclusions
Our study showed that patients with non-O blood groups require higher doses of warfarin.
Key Indexing Terms
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Article info
Publication history
Published online: April 10, 2020
Accepted:
March 30,
2020
Received:
October 19,
2019
Footnotes
There is no grant support.
Conflict of Interest: There are no conflicts of interest.
Identification
Copyright
© 2020 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
