ABSTRACT
Background
Hyperuricemia is associated with the development, progression and outcome of several
diseases. The purpose of this study is to evaluate the serum uric acid (UA) levels
as a predictor of long-term mortality in an older population (age 60 years and above).
Materials and Methods
Patients older than 60 years who were hospitalized in the departments of geriatrics
and internal medicine in Shaare Zedek Medical Center in Jerusalem during a period
of 4 months (March-June 2014) were included in this observational study. Association
between hyperuricemia and long-term mortality were analyzed using multiple logistic
regression, Kaplan-Meier and Cox proportional hazards regressions analysis.
Results
A total of 624 patients were included in our study with mean age of 77.2 ± 14.6 years.
Overall, 381 patients died during the follow-up period (61.1%). Mortality rate in
the hyperuricemic group (> 7 mg/dL) was higher (69.1%) than in the normouricemic group
58.4%. (P = 0.004). The median survival for hyperuricemic patients was significantly shorter
compared to normouricemic patients (606 and 1018 days, respectively, P < 0.0001). High levels of UA were significantly associated with higher long-term
mortality in patients with cardiovascular disease at their admission (P < 0.000).
Conclusions
Elevated levels of UA in older patients in acute settings is a predictor of long-term
mortality.
Key Indexing Terms
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Article info
Publication history
Published online: November 07, 2019
Accepted:
October 31,
2019
Received:
July 9,
2019
Footnotes
The authors have no financial or other conflicts of interest to disclose.
Identification
Copyright
© 2019 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
