ABSTRACT
Background
Ulcerative Colitis (UC) is characterized by chronic inflammation of the mucosal layers
of the colon. Treatment of refractory UC is challenging and has a huge healthcare
burden. Although there have been advancements in immunomodulatory therapies, these
require a step-up financially, and these medications are also associated with significant
adverse events. Curcumin, an active ingredient of turmeric, has been studied in the
past and found to be useful in the treatment of UC when used as an adjuvant along
with mesalamine. We did a systematic review and meta-analysis to explore the role
curcumin plays in clinical and endoscopic remission in patients with UC.
Materials and Methods
A comprehensive literature review was conducted by first searching the MEDLINE, Pubmed,
and Embase databases through December 2017 to identify all studies that compared the
use of curcumin when used along with mesalamine with placebo for clinical and endoscopic
improvement and remission.
Results
Three randomized controlled trials including 142 patients were included in the study.
Use of curcumin along with mesalamine was associated with increased odds of clinical
remission (pooled odds ratio of 6.78, 95% CI: 2.39-19.23, P = 0.042). Clinical improvement, endoscopic remission and improvement rate also trended
higher in the curcumin group compared to placebo.
Conclusions
This study demonstrates higher clinical remission rates when curcumin was used in
combination with mesalamine to achieve remission in patients with UC. Curcumin, due
to its cost effectiveness and safer side effect profile, can decrease the healthcare
burden and morbidity associated with this relapsing and remitting disease.
Key Indexing Terms
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Article info
Publication history
Published online: July 02, 2018
Accepted:
June 25,
2018
Received:
February 20,
2018
Footnotes
☆The authors have no financial or other conflicts of interest to disclose.
✯✯Source of funding: None declared.
Identification
Copyright
© 2018 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
