Abstract
Background
Gastric emptying (GE) of solids is delayed and autonomic dysfunction is detected in
autoimmune gastritis (AIG). The goals of this study were to: (1) compare serum levels
of ghrelin and motilin in subjects with delayed and normal GE and (2) investigate
whether circulating antimyenteric antibodies (CAA), serum ghrelin levels and motilin
levels have any effect on autonomic function.
Materials and Methods
Noninvasive cardiovascular reflex tests were used in order to evaluate the autonomic
function. GE was evaluated by a standard 2-hour scintigraphic test. Serum ghrelin
and motilin levels were tested by enzyme-linked immunosorbent assay and CAA were tested
by immunofluorescence.
Results
The serum ghrelin and motilin levels in the patients with delayed GE (n = 22) were significantly decreased compared to the normal GE patients (n = 19), (67.55 ± 8.81 versus 126.79 ± 25.81 pg/mL, P < 0.001 and 279.59 ± 111.12 versus 500.42 ± 155.95 pg/mL, respectively, P < 0.001). Whereas, the serum ghrelin and motilin levels in the patients with deranged
autonomic function (n = 26) were significantly decreased compared to the patients with normal autonomic function
(n = 15), (80.73 ± 28.46 versus 127.79 ± 28.06 pg/mL, P < 0.001 and 316.92 ± 160.47 versus 490.20 ± 141.02 pg/mL, P < 0.001, respectively). None of the patients were positive for CAA.
Conclusions
Ghrelin and motilin levels in AIG subjects with delayed GE and deranged autonomic
function were significantly decreased. The decrease in serum ghrelin and plasma motilin
levels in AIG suggest their potential role in the delayed GE observed in these subjects.
Key Indexing Terms
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Article info
Publication history
Accepted:
December 5,
2017
Received:
July 4,
2017
Footnotes
☆The authors have no conflicts of interest to disclose.
☆☆Source of Funding: This study was supported by a Grant from Ankara University Scientific Research Project Council (Grant no. 16B0230003).
Identification
Copyright
© 2018 Southern Society for Clinical Investigation. Published by All rights reserved.
