Abstract
Background
Osteoporosis is associated with a poor quality of life and mortality. Proteinuria
contributes to vitamin D deficiency and osteoblast dysfunction. The correlation between
estimated glomerular filtration rate (eGFR) and bone density still remains elusive.
Therefore, we sought to investigate whether reduced eGFR or proteinuria are independently
associated with the osteoporotic risk.
Methods
We conducted a cross-sectional study using community-based health survey data from
January 2004 to December 2008 in southern Taiwan. Positive proteinuria was defined
as presence of 1+ or more urinary proteins on the dipstick. The bone density was measured
by calcaneal quantitative ultrasound (QUS). Subjects with T-score ≤ −2.5 were considered
as osteoporotic.
Results
A total of 21,271 subjects of whom 11.3% had proteinuria were analyzed. Proteinuric
participants were older, predominantly male, and more likely to have diabetes, hypertension,
or exercise less regularly (P < 0.001). Multiple linear regression analysis showed that male sex, body mass index,
regular exercise, eGFR and high density lipoprotein-cholesterol were positively correlated
with QUS T-scores, whereas age, systolic blood pressure and proteinuria were negatively
associated with QUS T-scores (P < 0.01). Compared with subjects in the highest eGFR tertile, those in the middle
and the lowest groups had adjusted ORs for osteoporosis of 1.31 (95% CI: 1.20-1.44)
and 2.46 (1.73-3.48), respectively. Additionally, the fully adjusted ORs of osteoporosis
were 1.15 (1.02-1.32) and 1.18 (1.05-1.33) for participants with 1+ and ≥2+ proteinuria,
respectively.
Conclusions
Reduced eGFR and proteinuria are significantly associated with risk for osteoporosis.
Key Indexing Terms
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Article info
Publication history
Published online: January 17, 2018
Accepted:
December 22,
2017
Received:
August 1,
2017
Footnotes
The authors have declared that no competing financial interest exists.
This work was supported by the grant from Chang Gung Memorial Hospital at Chiayi, Taiwan (CMRPG6A0273).
Identification
Copyright
© 2017 Southern Society for Clinical Investigation. Published by All rights reserved.
