Abstract
Background
Oxidative stress occuring in patients diagnosed with inflammatory bowel disease (IBD),
but the relationship between oxidative stress, disease activity and inflammatory markers
has not been well established.
Materials and Methods
A total of 30 patients diagnosed with IBD and 30 volunteers who had normal colonoscopies,
selected as controls, were used for this study. The serum levels of antioxidant enzymes
(catalase and glutathione peroxidase) and oxidative markers (malondialdehyde [MDA]
and total antioxidant capacity) were compared between the 2 groups. Furthermore, their
correlations with disease activity scores and inflammatory markers, especially the
fecal calprotectin, were examined.
Results
Catalase and glutathione peroxidase concentrations were significantly correlated with
the level of fecal calprotectin in patients with IBD. Nevertheless, there were no
significant correlations between the concentrations of the above-mentioned enzymes
and C-reactive protein, erythrocyte sedimentation rate or the activity scores of IBD
patients. It should be noted that MDA and total antioxidant capacity levels did not
correlate with the inflammatory markers or the disease activity scores.
Conclusions
There was a positive correlation between fecal calprotectin and serum antioxidant
enzymes in patients with IBD, but, there was no correlation between antioxidant and
oxidative markers in terms of disease activity scores. Hence, the observed significant
correlation between the antioxidant enzymes and the fecal calprotectin may be due
to either the pro-oxidant potential of calprotectin or its antioxidant role.
Key Indexing Terms
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Article info
Publication history
Accepted:
December 22,
2017
Received:
August 5,
2017
Footnotes
☆☆The authors have no conflicts of interest to disclose.
☆This project was funded by Hormozgan University of Medical Sciences as MSc thesis research Grant (Grant no. 9437).
Identification
Copyright
© 2017 Southern Society for Clinical Investigation. Published by All rights reserved.
