Abstract
Background
Growing evidence suggest that macrophage migration inhibitory factor (MIF) plays a
vital role in glucose metabolism. We aimed to ascertain whether MIF levels are altered
in subjects with prediabetes and also to determine the relationship between MIF and
metabolic parameters as well as visceral fat mass.
Material and Methods
This cross-sectional study included 40 subjects with prediabetes and 40 age-, body
mass index (BMI)- and sex-matched subjects with normal glucose tolerance. Circulating
MIF levels were measured using enzyme-linked immunosorbent assay. Metabolic parameters
of recruited subjects were evaluated. Visceral fat mass was measured using bioelectrical
impedance method.
Results
Circulating MIF levels were found to be elevated in subjects with prediabetes compared
to controls (26.46 ± 16.98 versus 17.44 ± 11.80 ng/mL, P = 0.007). MIF positively correlated with BMI, visceral fat mass and indirect indices
of homeostasis model assessment of insulin resistance. In linear regression model,
an independent association was found between MIF levels and metabolic parameters,
including BMI, visceral fat mass and homeostasis model assessment of insulin resistance.
Multivariate logistic regression analyses revealed that the odds ratio for prediabetes
was higher in subjects in the highest quartile of MIF compared to those in the lowest
quartile, after adjusting for potential confounders.
Conclusions
Increased MIF levels are associated with the elevation of prediabetic risk.
Key Indexing Terms
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Article info
Publication history
Published online: November 14, 2017
Accepted:
October 24,
2017
Received:
March 14,
2017
Footnotes
☆The authors have no financial or other conflicts of interest to disclose.
Identification
Copyright
© 2017 Southern Society for Clinical Investigation. Published by All rights reserved.
