Abstract
Background
This study aims to investigate whether or not curcumin (Cur) protects against myocardial
ischemia and reperfusion (MI/R) injury via endothelial nitric oxide synthase (eNOS)
activation.
Materials and Methods
The rats were randomly assigned to a sham group, an MI/R group, or a MI/R + Cur group.
Infarct size, cell apoptosis, oxidative stress, eNOS phosphorylation expression and
eNOS expression were measured.
Results
Cur reduced infarct size, cell apoptosis and oxidative stress compared with the MI/R
group. Additionally, Cur significantly decreased eNOS phosphorylation.
Conclusions
Cur reduced MI/R injury via activation of eNOS. These findings suggest that Cur may
be a promising therapeutic drug for MI/R injury.
Key Indexing Terms
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Article info
Publication history
Published online: September 01, 2017
Accepted:
August 9,
2017
Received in revised form:
August 4,
2017
Received:
March 7,
2017
Publication stage
In Press Journal Pre-ProofFootnotes
☆The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.
Identification
Copyright
© 2017 Published by Elsevier Inc.
