A 65-year-old otherwise healthy man presented to the emergency department with complaints of headache, aphasia, confusion and partial vision loss. He had presented to his primary care physician with a nodule on the left parieto-occipital region of his head, 4 months prior. The lesion had been excised in the emergency department. However, the sample had not been sent for pathologic analysis as it was believed to be a lipoma. In the emergency department, physical examination revealed a large soft-tissue mass as depicted in Figure A. Magnetic resonance imaging (T2-weighted image) of the head revealed a large tumor with erosion into the cranium accompanied by mass effect (Figure B). He was admitted to our solid tumor service where biopsy revealed proliferation of plasma cells with CD-138 immunostaining and kappa antibody immunoreactivity. The diagnosis of plasmacytoma was made, and the patient received 5 fractions of 2,000 cGy radiation therapy. He furthermore received chemotherapy with lenalidomide and dexamethasone. Response to therapy was successfully achieved, and the patient was referred to surgery for cranioplasty. Extramedullary plasmacytoma is a rare tumor that usually arises from the head and neck, and is predominantly seen in men with a median age of 55 years.
1The 10-year overall survival rate is 70%.
- Kilciksiz S.
- Karakoyun-Celik O.
- Agaoglu F.Y.
- et al.
A review for solitary plasmacytoma of bone and extramedullary plasmacytoma..
Sci World J. 2012; : 895765
- Dimopoulos M.A.
- Hamilos G.
Solitary bone plasmacytoma and extramedullary plasmacytoma..
Curr Treat Options Oncol. 2002; 3: 255-259
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- A review for solitary plasmacytoma of bone and extramedullary plasmacytoma..Sci World J. 2012; : 895765
- Solitary bone plasmacytoma and extramedullary plasmacytoma..Curr Treat Options Oncol. 2002; 3: 255-259
© 2016 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.