ABSTRACT
Obesity can profoundly alter pulmonary function and diminish exercise capacity by
its adverse effects on respiratory mechanics, resistance within the respiratory system,
respiratory muscle function, lung volumes, work and energy cost of breathing, control
of breathing, and gas exchange. Weight loss can reverse many of the alterations of
pulmonary function produced by obesity. Obesity places the patient at risk of aspiration
pneumonia, pulmonary thromboembolism, and respiratory failure. It is the most common
precipitating factor for obstructive sleep apnea and is a requirement for the obesity
hypoventilation syndrome, both of which are associated with substantial morbidity
and increased mortality. There are numerous medical and surgical therapies for obstructive
sleep apnea and obesity hypoventilation. Weight reduction in the obese is among the
most effective of these measures.
KEY INDEXING TERMS
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© 2001 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
