ABSTRACT
Symptoms of intravascular volume overload and increased cardiac filling pressures
in the systemic and pulmonary venous circulations are among the most common complaints
in patients with chronic heart failure (CHF). The clinical utility of physical examination
for estimation of intravascular volume status in patients with CHF is limited due
to poor specificity and sensitivity of most signs of congestion. Direct measurement
of blood volume with radioisotope techniques is FDA-approved and has been shown to
be closely associated with invasive measurements of cardiac filling pressures in patients
with CHF. Unrecognized volume overload is common in CHF patients and is associated
with adverse clinical outcomes. Additional work is needed to determine the clinical
utility of serial blood volume measurements in the management of patients with CHF.
KEY INDEXING TERMS
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© 2007 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
