Abstract
Background
The prevalence of reduced estimated glomerular filtration rate (eGFR) among U.S. adults
aged 80 years and older increased between 1988 to 1994 and 2005 to 2010. Trends in
the prevalence of albuminuria over this time period have not been reported in this
population.
Methods
We conducted a cross-sectional analysis of U.S. adults aged 80 years and older in
the National Health and Nutrition Examination Survey 1988 to 1994 (n=1020), 1999 to 2004 (n=995) and 2005 to 2010 (n=971) to calculate the prevalence of albuminuria (albumin-to-creatinine ratio [ACR]
≥30 mg/g) by calendar period. The number of U.S. adults aged 80 years and older with elevated
ACR and separately reduced eGFR was calculated by calendar period.
Results
Among participants aged 80 years and older, the prevalence of albuminuria was 30.9%,
33.0% and 30.6% in 1988 to 1994, 1999 to 2004 and 2005 to 2010 (P=0.9). The proportion of U.S. adults aged 80 years and older with both eGFR <45 ml/min/1.73 m−2 and ACR ≥30 mg/g increased from 6.8% in 1988 to 1994 to 8.4% and 9.5% in 1999 to 2004 and 2005
to 2010, respectively (P=0.008). In 1988 to 1994, 1999 to 2004 and 2005 to 2010, there were 1.78 (95% confidence
interval [CI], 1.29–2.27), 2.35 (95% CI, 1.93-2.78) and 2.74 (95% CI, 2.32–3.16) million
U.S. adults aged 80 years older with albuminuria and 2.34 (95% CI, 1.79–2.89), 3.55
(95% CI, 2.96–4.14) and 4.58 (95% CI, 3.87–5.28) million, respectively, with eGFR
<60 ml/min/1.73 m−2.
Conclusions
The proportion of U.S. adults aged 80 years and older with an elevated ACR remained
relatively stable between 1988 to 1994 and 2005 to 2010. However, due to the growth
of the oldest-old, the absolute number with albuminuria increased substantially over
the past 2 decades.
Key Indexing Terms
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Article info
Footnotes
Support was provided through National Institute on Aging (R03AG042336–01), the T. Franklin Williams Scholarship Award (funding provided by Atlantic Philanthropies, Inc, the John A. Hartford Foundation, the Association of Specialty Professors, the American Society of Nephrology and the American Geriatrics Society) and the Veterans Health Administration Clinical Science Research & Development (1IK2CX000856-01A1).
The authors have no financial or other conflicts of interest to disclose.
Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.amjmedsci.com).
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© 2014 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
