Abstract
Background
Pulse wave velocity is a marker of arterial stiffness. Unequal arterial stiffness
has been associated with increased risk of cardiovascular events. This study calculated
bilateral brachial-ankle pulse wave velocity (baPWV) differences and investigated
the associations of unequal bilateral baPWV with overall and cardiovascular mortality
in patients receiving hemodialysis (HD).
Materials and Methods
A total of 205 patients receiving HD were enrolled in this study. The mean follow-up
period was 4.4 ± 1.5 years. The baPWV was measured using an ankle-brachial index-form
device, and bilateral baPWV difference was calculated and defined as ΔbaPWV.
Results
The median value of ΔbaPWV was 88 cm/second. ankle-brachial index < 0.95 and high baPWV were independently associated
with a ΔbaPWV ≥ 88 cm/s. Furthermore, patients with a ΔbaPWV ≥ 88 cm/s demonstrated poorer overall (log-rank P = 0.035) and cardiovascular (log-rank P = 0.036) survival than did those with a ΔbaPWV < 88 cm/s. After multivariate analysis, this difference was independently associated with
overall (hazard ratio = 1.006; 95% CI: 1.001-1.011; P = 0.024) and cardiovascular (hazard ratio = 1.006; 95% CI: 1.000-1.013; P = 0.049) mortality.
Conclusions
ΔbaPWV was associated with an increased risk of cardiovascular and overall mortality
in patients receiving HD. Earlier evaluation of ΔbaPWV may facilitate the identification
of patients receiving HD who have an increased risk of cardiovascular and overall
mortality.
Key Indexing Terms
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Article info
Publication history
Accepted:
October 22,
2016
Received:
July 3,
2015
Footnotes
The authors have no financial or other conflicts of interest to disclose.
Identification
Copyright
© 2016 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
