Abstract
Objective
Cognitive and cardiovascular disorders share many risk factors. Higher bone-marrow
derived progenitor cells (PC) in blood are associated with lower rates of cardiovascular
events but the association of PC with cognitive function is unclear. The objective
of this study was to assess the association between PC and cognition in a sample of
healthy adults enrolled in a cohort study.
Materials and Methods
A random sample of employees at Emory University and Georgia Institute of Technology
were followed for 4 years and underwent yearly vascular and cognitive assessment (N = 430, mean age = 49.2 years, 70% women, and 27% African-American). Cognition was
assessed using computerized versions of 15 cognitive tests and principal component
analysis was used for deriving cognitive scores: executive function, memory and working
memory. PC were defined as mononuclear cells with specific surface markers (7 phenotypes).
Decreased cognition in a domain was defined as performing below the lowest quartile
for the corresponding domain at baseline. Generalized estimating equations were used
to investigate associations between PC and cognition.
Results
Higher PC levels at baseline were associated with lower risk of cognitive decline
in the executive and working memory domains during the follow-up period (P < 0.002 for all PC phenotypes). Further, the degree of decline in PC over the follow-up
period was correlated with a corresponding decline in performances in all 3 cognitive
domains over the same period (All P < 0.002).
Conclusion
Lower PC and greater yearly declines in PC are associated with greater cognitive decline.
These findings suggest the role for PC in neurocognitive aging.
Key Indexing Terms
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to The American Journal of the Medical SciencesAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Cardiovascular disease risk factors and cognition in the elderly.Curr Cardiovasc rRsk Rep. 2011; 5: 407-412
- Circulating endothelial progenitor cells and cardiovascular outcomes.N Engl J Med. 2005; 353: 999-1007
- Circulating bone marrow-derived endothelial progenitor cells: characterization, mobilization, and therapeutic considerations in malignant disease.Cytometry Part A. 2008; 73: 186-193
- Endothelial progenitor cells: current issues on characterization and challenging clinical applications.Stem Cell Rev. 2012; 8: 926-939
- Endothelial progenitor cells and vascular repair.Curr Opin Hematol. 2014; 21: 224-228
- Circulating endothelial progenitor cells, vascular function, and cardiovascular risk.N Engl J Med. 2003; 348: 593-600
- Endothelial progenitor cells and cerebrovascular diseases.Prog Neurobiol. 2007; 83: 349-362
- Endothelial progenitor cells in patients with acute cerebrovascular ischemia.Can J Neurol Sci. 2010; 37: 797-802
- The increase of circulating endothelial progenitor cells after acute ischemic stroke is associated with good outcome.Stroke. 2007; 38: 2759-2764
- Circulating endothelial progenitor cells and age-related white matter changes.Stroke. 2009; 40: 3191-3196
- Endothelial progenitor cells with Alzheimer׳s disease.Chin Med J. 2011; 124: 901-906
- Effects of adult age and blood pressure on executive function and speed of processing.Exp Aging Res. 2010; 36: 153-168
- Integrating comparative effectiveness research programs into predictive health: a unique role for academic health centers.Acad Med. 2011; 86: 718-723
- Isolation of putative progenitor endothelial cells for angiogenesis.Science. 1997; 275: 964-967
- Critical reevaluation of endothelial progenitor cell phenotypes for therapeutic and diagnostic use.Circ Res. 2012; 110: 624-637
- Computerized methods in the assessment and prediction of dementia.Curr Alzheimer Res. 2007; 4: 364-369
- Computerized diagnosis of mild cognitive impairment.Alzheimers Dement. 2007; 3: 23-27
- Human-computer interaction in the administration and analysis of neuropsychological tests.Comput Methods Programs Biomed. 2004; 73: 43-53
Jackson DJ, Borgatta EF. Factor analysis and measurement in sociological research: a multi-dimensional perspective. Selecting a Data Analysis Model for Factorial Ecology Research. Beverly Hills, Calif.: Sage Publications; 1981 [chapter].
- Confirmatory Factor Analysis for Applied Research.Guilford Press, New York2006
- Calculations for risk or prevalence ratios and differences.Am J Epidemiol. 2005; 162: 199-200
- Alzheimer׳s disease affects progenitor cells through aberrant {beta}-catenin signaling.J Neurosci. 2009; 29: 12369-12371
- Dysfunctional characteristics of circulating angiogenic cells in Alzheimer׳s disease.J Alzheimers Dis. 2010; 19: 1231-1240
- Bone marrow-derived progenitor cells in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.Stroke. 2010; 41: 218-223
- Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association.Stroke. 2011; 42: 2672-2713
- Endothelial progenitor cells, endothelial dysfunction, inflammation, and oxidative stress in hypertension.Antioxid Redox Signal. 2008; 10: 1079-1088
- Bone marrow-derived endothelial progenitor cells participate in cerebral neovascularization after focal cerebral ischemia in the adult mouse.Circ Res. 2002; 90: 284-288
- Early brain injury alters the blood-brain barrier phenotype in parallel with beta-amyloid and cognitive changes in adulthood.J Cereb Blood Flow Metab. 2013; 33: 205-214
- Instruction of circulating endothelial progenitors in vitro towards specialized blood-brain barrier and arterial phenotypes.PLoS One. 2014; 9: e84179
- Circadian variation in vascular function and regenerative capacity in healthy humans.J Am Heart Assoc. 2014; 3: e000845
- Effect of progenitor cell mobilization with granulocyte-macrophage colony-stimulating factor in patients with peripheral artery disease: a randomized clinical trial.J Am Med Assoc. 2013; 310: 2631-2639
- Bone marrow mobilization with granulocyte macrophage colony-stimulating factor improves endothelial dysfunction and exercise capacity in patients with peripheral arterial disease.Am Heart J. 2009; 158: 53-60 e51
Article info
Publication history
Accepted:
September 14,
2015
Received:
July 2,
2015
Footnotes
The authors have no financial or other conflicts of interest to disclose.
Identification
Copyright
© 2016 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
